Coot is a powerful macromolecular model-building tool for
analysing X-ray data and models (i.e. proteins, ligands, RNA and
DNA). There are many tools for model manipulation and building,
such as minimization, molecular superposition, fragment
rotation/translations, rotamer-fitting, de novo building and
refinement.

Coot is used by scientists using X-ray crystallography or cryo-EM for
analysis of proteins, electron density maps, protein interactions
and drug design.