An improved version of MECAT. It is an ultra-fast and accurate mapping and error correcting de novo assembly tools for single molecula sequencing (SMRT) reads. MECAT2 consists of the following three modules: 1. mecat2map: a fast and accurate alignment tool for SMRT reads. 2. mecat2cns: correct noisy reads based on their pairwise overlaps. 3. fsa: a string graph based assembly tool.