This package provides prof(1), the protein secondary structure, accessibility and transmembrane helix predictor from Burkhard Rost. Prediction is either done from protein sequence alone or from an alignment - the latter should be used for optimal performance.

How well does prof(1) perform?

* Secondary structure is predicted at an expected average accuracy > 72% for
the three states helix, strand and loop.
* Solvent accessibility is predicted at a correlation coefficient
(correlation between experimentally observed and predicted relative
solvent accessibility) of 0.54
* Transmembrane helix prediction has an expected per-residue accuracy of
about 95%. The number of false positives, i.e., transmembrane helices
predicted in globular proteins, is about 2%.