R package for anlaysis of ChIP-seq and other functional sequencing data
* Assess overall DNA-binding signals in the data and select appropriate
quality of tag alignment.
* Discard or restrict positions with abnormally high number of tags.
* Calculate genome-wide profiles of smoothed tag density and save them
in WIG files for viewing in other browsers.
* Calculate genome-wide profiles providing conservative statistical
estimates of fold enrichment ratios along the genome. These can be
exported for browser viewing, or thresholded to determine regions of
significant enrichment/depletion.
* Determine statistically significant point binding positions
* Assess whether the set of point binding positions detected at a
current sequencing depth meets saturation criteria, and if does not,
estimate what sequencing depth would be required to do so.