snpsift

tool to annotate and manipulate genome variants - tool
  https://pcingola.github.io/SnpEff/ss_introduction/
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SnpSift is a toolbox that allows one to filter and manipulate annotated files. Once the genomic variants have been annotated, one needs to filter them out in order to find the "interesting / relevant variants". Given the large data files, this is not a trivial task (e.g. one cannot load all the variants into XLS spreadsheet). SnpSift helps to perform this VCF file manipulation and filtering required at this stage in data processing pipelines.

This package contains the command line tool.