TIPP is a modification of SEPP for classifying query sequences (i.e. reads) using phylogenetic placement.

TIPP inserts each read into a taxonomic tree and uses the insertion location to identify the taxonomic lineage of the read. The novel idea behind TIPP is that rather than using the single best alignment and placement for taxonomic identification, it uses a collection of alignments and placements and considers statistical support for each alignment and placement.

TIPP can also be used for abundance estimation by computing an abundance profile on the reads binned to marker genes in a reference dataset.