vt

toolset for short variant discovery in genetic sequence data
  https://genome.sph.umich.edu/wiki/Vt
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Vt is a variant tool set that discovers short variants from Next Generation Sequencing data.

Vt-normalize is a tool to normalize representation of genetic variants in the VCF. Variant normalization is formally defined as the consistent representation of genetic variants in an unambiguous and concise way. In vt a simple general algorithm to enforce this is implemented.